Isabel De Obaldia was born in Washington D.C. in 1957 of French and Panamanian parents. De Obaldia was raised in Panama, where her father, Guillermo Trujillo is a celebrated painter. She studied architecture at the University of Panama and drawing at the Ecole de Beaux Arts in Paris. She received her B.F.A. in Graphic Design and Cinematography from the Rhode Island School of Design in 1979. She went on to study at the Art Students League in NYC in 1982. Since 1987, she has worked with glass at the world- renowned Pilchuck Glass School, where she is a member of the International Council Member.

De Obaldia received the Creative Glass Center of America Fellowship at Wheaton Arts in 2006. She goes back to Wheaton frequently to do her large scale sand castings. In 2009 she was the recipient of the Rakow Commission of the Corning Museum of Glass.

The Museum of Art of Ft. Lauderdale had a retrospective exhibition of her work “Primordial: Paintings and Sculpture by Isabel De Obaldia” from September 2011 through May 2012.

De Obaldia currently lives and works in Panama City.
She is represented in the U.S. by NYC based gallery Mary-Anne Martin/Fine Art.